Targeting Innate Immunity to Enhance the Efficacy of Radiation Therapy.
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ABSTRACT:
SUBMITTER: Dar TB
PROVIDER: S-EPMC6339921 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Publications
Targeting Innate Immunity to Enhance the Efficacy of Radiation Therapy.
Dar Tahir B TB Henson Regina M RM Shiao Stephen L SL
Frontiers in immunology 20190114
Radiation continues to play a major role in the treatment of almost every cancer type. Traditional radiation studies focused on its ability to damage DNA, but recent evidence has demonstrated that a key mechanism driving the efficacy of radiation <i>in vivo</i> is the immune response triggered in irradiated tissue. Innate immune cells including macrophages, dendritic cells, and natural killer cells are key mediators of the radiation-induced immune response. They regulate the sensing of radiation ...[more]
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