Ontology highlight
ABSTRACT:
SUBMITTER: Styfhals R
PROVIDER: S-EPMC6339937 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Frontiers in physiology 20190114
Connecting millions of neurons to create a functional neural circuit is a daunting challenge. Vertebrates developed a molecular system at the cell membrane to allow neurons to recognize each other by distinguishing self from non-self through homophilic protocadherin interactions. In mammals, the protocadherin gene family counts about 50 different genes. By hetero-multimerization, protocadherins are capable of generating an impressive number of molecular interfaces. Surprisingly, in the Californi ...[more]