Ontology highlight
ABSTRACT:
SUBMITTER: Barenz F
PROVIDER: S-EPMC6340214 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Bärenz Felix F Kschonsak Yvonne T YT Meyer Annalena A Jafarpour Aliakbar A Lorenz Holger H Hoffmann Ingrid I
Molecular biology of the cell 20181024 26
Microtubule nucleation was uncovered as a key principle of spindle assembly. However, the mechanistic details about microtubule nucleation and the organization of spindle formation and symmetry are currently being revealed. Here we describe the function of coiled-coil domain containing 61 (Ccdc61), a so far uncharacterized centrosomal protein, in spindle assembly and symmetry. Our data describe that Ccdc61 is required for spindle assembly and precise chromosome alignments in mitosis. Microtubule ...[more]