Precision medicine approaches for the management of Ewing sarcoma: current perspectives.
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ABSTRACT:
SUBMITTER: Rizk VT
PROVIDER: S-EPMC6340366 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Publications
Precision medicine approaches for the management of Ewing sarcoma: current perspectives.
Rizk Victoria T VT Walko Christine M CM Brohl Andrew S AS
Pharmacogenomics and personalized medicine 20190117
Advancements in molecular and genetic techniques have significantly furthered our biological understanding of Ewing sarcoma (ES). ES is typified by a driving TET-ETS fusion with an otherwise relatively quiet genome. Detection of one of several characteristic fusions, most commonly <i>EWSR1-FLI1</i>, is the gold standard for diagnosis. We discuss the current role of precision medicine in the diagnosis, treatment, and monitoring of ES. Continued efforts toward molecularly guided approaches are act ...[more]
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