Dataset Information

Association between the concurrence of pre-existing chronic liver disease and worse prognosis in patients with an herb- Polygonum multiflorum thunb. induced liver injury: a case-control study from a specialised liver disease center in China.

ABSTRACT:

Objectives

The present study aimed to evaluate the association between the concurrence of pre-existing chronic liver diseases (CLD) and worse prognosis in patients with HILI.

Design

A case-control study.

Setting

Tertiary hospital specialising in liver diseases in China.

Participants

145 hospitalised HILI patients were assessed with respect to prognosis by comparing HILI with or without pre-existing CLD from February 2007 to January 2017. Twenty-five HILI cases with pre-existing alcoholic liver disease (ALD) or non-alcoholic fatty liver disease (NAFLD) and 200 ALD or NAFLD controls matched 1:8 for sex, age (±4 years old), body mass index (±2?kg/m²), the type of CLD, alcohol intake (±5?g/d) and the presence or absence of cirrhosis.

Primary outcome measures

Mortality and chronicity in HILI patients with or without pre-existing CLD, and matched CLD patients.

Results

Of the 193?714 hospitalised patients with liver diseases, 5703 patients met the diagnostic criteria for drug-induced liver injury (DILI), which was attributed to Polygonum multiflorum Thunb. (PMT) in 145 patients. Among these HILI patients, 22.8% (33 of 145) had pre-existing CLD, including 17 (51.5%) with ALD, 8 (24.2%) with NAFLD, 5 (15.2%) with chronic viral hepatitis and 3 (9.1%) with autoimmune liver disease. Compared with HILI patients without CLD, HILI patients with pre-existing CLD showed higher mortality (0.9% vs 9.1%, p=0.037) and higher chronicity (12.5% vs 30.3%, p=0.016). Compared with matched ALD (136 patients) or NAFLD (64 patients) patients, HILI patients with pre-existing ALD showed higher chronicity (35.3% vs 11.8%, p=0.019). Multivariate logistic regression analysis found that concurrence of pre-existing CLD was an independent risk factor for both of chronicity and mortality (OR 3.966, 95%?CI 1.501 to 10.477, p=0.005), especially the chronicity (OR 3.035, 95%?CI 1.115 to 8.259, p=0.030).

Conclusions

Concurrence of pre-existing CLD could be an independent risk factor for worse prognosis, especially chronicity, in PMT-related HILI.

SUBMITTER: Jing J

PROVIDER: S-EPMC6340630 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature

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Association between the concurrence of pre-existing chronic liver disease and worse prognosis in patients with an herb- <i>Polygonum multiflorum</i> thunb. induced liver injury: a case-control study from a specialised liver disease center in China.

Jing Jing J Wang Rui-Lin RL Zhao Xin-Yan XY Zhu Yun Y Niu Ming M Wang Li-Fu LF Song Xue-Ai XA He Ting-Ting TT Sun Yong-Qiang YQ Xu Wen-Tao WT Yu Si-Miao SM Wang Li-Ping LP Guo Yu-Ming YM Bai Zhao-Fang ZF Xiao Xiao-He XH Wang Jia-Bo JB

BMJ open 20190115 1

<h4>Objectives</h4>The present study aimed to evaluate the association between the concurrence of pre-existing chronic liver diseases (CLD) and worse prognosis in patients with HILI.<h4>Design</h4>A case-control study.<h4>Setting</h4>Tertiary hospital specialising in liver diseases in China.<h4>Participants</h4>145 hospitalised HILI patients were assessed with respect to prognosis by comparing HILI with or without pre-existing CLD from February 2007 to January 2017. Twenty-five HILI cases with p ...[more]

PMID: 30782709

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