Ontology highlight
ABSTRACT:
SUBMITTER: Lorusso S
PROVIDER: S-EPMC6340713 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Lorusso Samantha S Kline David D Bartlett Amy A Freimer Miriam M Agriesti Julie J Hawash Ahmed A AA Rich Mark M MM Kissel John T JT David Arnold W W
Muscle & nerve 20181221 2
<h4>Introduction</h4>Paramyotonia congenita (PMC) is a nondystrophic myotonic disorder that is believed to be caused by a defect in Na<sub>v</sub> 1.4 sodium channel inactivation. Ranolazine, which acts by enhancing slow inactivation of sodium channels, has been proposed as a therapeutic option, but in vivo studies are lacking.<h4>Methods</h4>We conducted an open-label, single-center trial of ranolazine to evaluate efficacy and tolerability in patients with PMC. Subjective symptoms of stiffness, ...[more]