Ontology highlight
ABSTRACT:
SUBMITTER: Abrahams CL
PROVIDER: S-EPMC6340874 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Abrahams Cristina L CL Li Xiaofan X Embry Millicent M Yu Abigail A Krimm Stellanie S Krueger Sarah S Greenland Nancy Y NY Wen Kwun Wah KW Jones Chris C DeAlmeida Venita V Solis Willy A WA Matheny Shannon S Kline Toni T Yam Alice Y AY Stafford Ryan R Wiita Arun P AP Hallam Trevor T Lupher Mark M Molina Arturo A
Oncotarget 20181228 102
STRO-001 is a site-specific, predominantly single-species, fully human, aglycosylated anti-CD74 antibody-drug conjugate incorporating a non-cleavable linker-maytansinoid warhead with a drug-antibody ratio of 2 which was produced by a novel cell-free antibody synthesis platform. We examined the potential pharmacodynamics and anti-tumor effects of STRO-001 in multiple myeloma (MM). CD74 expression was assessed in MM cell lines and primary bone marrow (BM) MM biopsies. CD74 mRNA was detectable in C ...[more]