An integrated chromatin accessibility and transcriptome landscape of human pre-implantation embryos.
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ABSTRACT:
SUBMITTER: Liu L
PROVIDER: S-EPMC6341076 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Publications
An integrated chromatin accessibility and transcriptome landscape of human pre-implantation embryos.
Liu Longqi L Leng Lizhi L Liu Chuanyu C Lu Changfu C Yuan Yue Y Wu Liang L Gong Fei F Zhang Shuoping S Wei Xiaoyu X Wang Mingyue M Zhao Lei L Hu Liang L Wang Jian J Yang Huanming H Zhu Shida S Chen Fang F Lu Guangxiu G Shang Zhouchun Z Lin Ge G
Nature communications 20190121 1
Human pre-implantation embryonic development involves extensive changes in chromatin structure and transcriptional activity. Here, we report on LiCAT-seq, a technique that enables simultaneous profiling of chromatin accessibility and gene expression with ultra-low input of cells, and map the chromatin accessibility and transcriptome landscapes for human pre-implantation embryos. We observed global difference in chromatin accessibility between sperm and all stages of embryos, finding that the acc ...[more]
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