Ontology highlight
ABSTRACT:
SUBMITTER: Kliewer A
PROVIDER: S-EPMC6341117 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Kliewer A A Schmiedel F F Sianati S S Bailey A A Bateman J T JT Levitt E S ES Williams J T JT Christie M J MJ Schulz S S
Nature communications 20190121 1
Opioid analgesics are powerful pain relievers; however, over time, pain control diminishes as analgesic tolerance develops. The molecular mechanisms initiating tolerance have remained unresolved to date. We have previously shown that desensitization of the μ-opioid receptor and interaction with β-arrestins is controlled by carboxyl-terminal phosphorylation. Here we created knockin mice with a series of serine- and threonine-to-alanine mutations that render the receptor increasingly unable to rec ...[more]