Dataset Information

Phytochemical profiles and classification of Agave syrups using 1H-NMR and chemometrics.

ABSTRACT: Background:Agave syrups are natural sweeteners that are highly desirable for human consumption because they have low glycemic index. In this work, we explored the potential of 1H-NMR-Chemometrics as a useful tool in the identification and differentiation of Agave syrups. Also, we evaluated the phytochemical screening and antioxidant capacity of Agave syrup compared to other natural sweeteners. Results:The phytochemical screening stands out for Agave syrups containing higher levels of metabolites with antioxidant activity, mainly saponins, glycosides, and terpenoids. Agave syrup antioxidant activity was in a range from 10% to 53%, while the total phenolic content was from 24 to 300 EAG/100 g, and condensed tannins were between 240 and 1,900 mg CE/g. Additionally, 1H-NMR spectroscopy was used to characterize syrup profiles and chemometrics. PCA group analyses allowed the sweeteners' classification by origin and kind of Agave. Conclusion:Thus, we conclude that 1H-NMR and chemometrics can be used for identifying, differentiating, and classifying Agave syrups. Besides, Agave syrups contain significant amounts of antioxidative components and can be considered as an effective source of antioxidant.

SUBMITTER: Velazquez Rios IO

PROVIDER: S-EPMC6341176 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature

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Phytochemical profiles and classification of Agave syrups using <sup>1</sup>H-NMR and chemometrics.

Velázquez Ríos Irving O IO González-García Gerardo G Mellado-Mojica Erika E Veloz García Rafael A RA Dzul Cauich Jorge G JG López Mercedes G MG García-Vieyra María I MI

Food science & nutrition 20181119 1

<h4>Background</h4>Agave syrups are natural sweeteners that are highly desirable for human consumption because they have low glycemic index. In this work, we explored the potential of <sup>1</sup>H-NMR-Chemometrics as a useful tool in the identification and differentiation of Agave syrups. Also, we evaluated the phytochemical screening and antioxidant capacity of Agave syrup compared to other natural sweeteners.<h4>Results</h4>The phytochemical screening stands out for Agave syrups containing hi ...[more]

PMID: 30680154

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Project description:Biomarkers currently available for the diagnosis, prognosis, and therapeutic monitoring of GM1 gangliosidosis type 2 (GM1T2) disease are mainly limited to those discovered in targeted proteomic-based studies. In order to identify and establish new, predominantly low-molecular-mass biomarkers for this disorder, we employed an untargeted, multi-analyte approach involving high-resolution 1H NMR analysis coupled to a range of multivariate analysis and computational intelligence technique (CIT) strategies to explore biomolecular distinctions between blood plasma samples collected from GM1T2 and healthy control (HC) participants (n = 10 and 28, respectively). The relationship of these differences to metabolic mechanisms underlying the pathogenesis of GM1T2 disorder was also investigated. 1H NMR-linked metabolomics analyses revealed significant GM1T2-mediated dysregulations in ≥13 blood plasma metabolites (corrected p < 0.04), and these included significant upregulations in 7 amino acids, and downregulations in lipoprotein-associated triacylglycerols and alanine. Indeed, results acquired demonstrated a profound distinctiveness between the GM1T2 and HC profiles. Additionally, employment of a genome-scale network model of human metabolism provided evidence that perturbations to propanoate, ethanol, amino-sugar, aspartate, seleno-amino acid, glutathione and alanine metabolism, fatty acid biosynthesis, and most especially branched-chain amino acid degradation (p = 10-12-10-5) were the most important topologically-highlighted dysregulated pathways contributing towards GM1T2 disease pathology. Quantitative metabolite set enrichment analysis revealed that pathological locations associated with these dysfunctions were in the order fibroblasts > Golgi apparatus > mitochondria > spleen ≈ skeletal muscle ≈ muscle in general. In conclusion, results acquired demonstrated marked metabolic imbalances and alterations to energy demand, which are consistent with GM1T2 disease pathogenesis mechanisms.

Dataset Information

Phytochemical profiles and classification of Agave syrups using 1H-NMR and chemometrics.

Publications

Phytochemical profiles and classification of Agave syrups using <sup>1</sup>H-NMR and chemometrics.

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