Ontology highlight
ABSTRACT:
SUBMITTER: Qi X
PROVIDER: S-EPMC6341491 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Qi Xiaofeng X Schmiege Philip P Coutavas Elias E Li Xiaochun X
Science (New York, N.Y.) 20180823 6410
Aberrant Hedgehog (HH) signaling leads to various types of cancer and birth defects. N-terminally palmitoylated HH initiates signaling by binding its receptor Patched-1 (PTCH1). A recent 1:1 PTCH1-HH complex structure visualized a palmitate-mediated binding site on HH, which was inconsistent with previous studies that implied a distinct, calcium-mediated binding site for PTCH1 and HH co-receptors. Our 3.5-angstrom resolution cryo-electron microscopy structure of native Sonic Hedgehog (SHH-N) in ...[more]