Mapping projections of molecularly defined dopamine neuron subtypes using intersectional genetic approaches.
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ABSTRACT:
SUBMITTER: Poulin JF
PROVIDER: S-EPMC6342021 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Publications
Mapping projections of molecularly defined dopamine neuron subtypes using intersectional genetic approaches.
Poulin Jean-Francois JF Caronia Giuliana G Hofer Caitlyn C Cui Qiaoling Q Helm Brandon B Ramakrishnan Charu C Chan C Savio CS Dombeck Daniel A DA Deisseroth Karl K Awatramani Rajeshwar R
Nature neuroscience 20180813 9
Midbrain dopamine (DA) neurons have diverse functions that can in part be explained by their heterogeneity. Although molecularly distinct subtypes of DA neurons have been identified by single-cell gene expression profiling, fundamental features such as their projection patterns have not been elucidated. Progress in this regard has been hindered by the lack of genetic tools for studying DA neuron subtypes. Here we develop intersectional genetic labeling strategies, based on combinatorial gene exp ...[more]
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