Ontology highlight
ABSTRACT:
SUBMITTER: Tian DD
PROVIDER: S-EPMC6342244 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Tian Dan-Dan DD Natesan Senthil S White John R JR Paine Mary F MF
Clinical and translational science 20181126 1
The caffeine metabolic ratio is an established marker for cytochrome P450 (CYP) 1A2 activity. Optimal sample size calculation for clinical pharmacokinetic xenobiotic-caffeine interaction studies requires robust estimates of interindividual and intraindividual variation in this ratio. Compared with interindividual variation, factors contributing to intraindividual variation are less defined. An exploratory analysis involving healthy nonsmoking non-naïve caffeine drinkers (1-3 cups/day; 12 men, 12 ...[more]