Ontology highlight
ABSTRACT:
SUBMITTER: Kim J
PROVIDER: S-EPMC6342284 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Cell reports 20181201 10
Enhancer of Zeste 2 (EZH2) is the enzymatic subunit of Polycomb Repressive Complex 2 (PRC2), which catalyzes histone H3 lysine 27 trimethylation (H3K27me3) at target promoters for gene silencing. Here, we report that EZH2 activates androgen receptor (AR) gene transcription through direct occupancy at its promoter. Importantly, this activating role of EZH2 is independent of PRC2 and its methyltransferase activities. Genome-wide assays revealed extensive EZH2 occupancy at promoters marked by eithe ...[more]