Unknown

Dataset Information

0

Thalamic reticular control of local sleep in mouse sensory cortex.


ABSTRACT: Sleep affects brain activity globally, but many cortical sleep waves are spatially confined. Local rhythms serve cortical area-specific sleep needs and functions; however, mechanisms controlling locality are unclear. We identify the thalamic reticular nucleus (TRN) as a source for local, sensory-cortex-specific non-rapid-eye-movement sleep (NREMS) in mouse. Neurons in optogenetically identified sensory TRN sectors showed stronger repetitive burst discharge compared to non-sensory TRN cells due to higher activity of the low-threshold Ca2+ channel CaV3.3. Major NREMS rhythms in sensory but not non-sensory cortical areas were regulated in a CaV3.3-dependent manner. In particular, NREMS in somatosensory cortex was enriched in fast spindles, but switched to delta wave-dominated sleep when CaV3.3 channels were genetically eliminated or somatosensory TRN cells chemogenetically hyperpolarized. Our data indicate a previously unrecognized heterogeneity in a powerful forebrain oscillator that contributes to sensory-cortex-specific and dually regulated NREMS, enabling local sleep regulation according to use- and experience-dependence.

SUBMITTER: Fernandez LM 

PROVIDER: S-EPMC6342525 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature

altmetric image

Publications

Thalamic reticular control of local sleep in mouse sensory cortex.

Fernandez Laura Mj LM   Vantomme Gil G   Osorio-Forero Alejandro A   Cardis Romain R   Béard Elidie E   Lüthi Anita A  

eLife 20181225


Sleep affects brain activity globally, but many cortical sleep waves are spatially confined. Local rhythms serve cortical area-specific sleep needs and functions; however, mechanisms controlling locality are unclear. We identify the thalamic reticular nucleus (TRN) as a source for local, sensory-cortex-specific non-rapid-eye-movement sleep (NREMS) in mouse. Neurons in optogenetically identified sensory TRN sectors showed stronger repetitive burst discharge compared to non-sensory TRN cells due t  ...[more]

Similar Datasets

| S-EPMC4281280 | biostudies-literature
| S-EPMC4700269 | biostudies-literature
| S-EPMC4626291 | biostudies-literature
| S-EPMC6401113 | biostudies-literature
| S-EPMC6438460 | biostudies-literature
| S-EPMC10066598 | biostudies-literature
| S-EPMC7394718 | biostudies-literature
2023-03-31 | GSE226333 | GEO
2023-04-24 | GSE210720 | GEO
| S-EPMC5027246 | biostudies-literature