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Magnetic resonance T1w/T2w ratio: A parsimonious marker for Parkinson disease.

ABSTRACT: OBJECTIVE:Newer magnetic resonance imaging (MRI) techniques have shown promise in capturing early Parkinson disease (PD)-related changes in the substantia nigra pars compacta (SNc), the key pathological loci. Their translational value, however, is hindered by technical complexity and inconsistent results. METHODS:A novel yet simple MRI contrast, the T1w/T2w ratio, was used to study 76 PD patients and 70 controls. The T1w/T2w ratio maps were analyzed using both voxel-based and region-of-interest approaches in normalized space. The sensitivity and specificity of the SNc T1w/T2w ratio in discriminating between PD and controls also were assessed. In addition, its diagnostic performance was tested in a subgroup of PD patients with disease duration??2 years (PDE). A second independent cohort of 73 PD patients and 49 controls was used for validation. RESULTS:Compared to controls, PD patients showed a higher T1w/T2w ratio in both the right (cluster size?=?164mm3 , p?

SUBMITTER: Du G

PROVIDER: S-EPMC6342624 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature

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Magnetic resonance T1w/T2w ratio: A parsimonious marker for Parkinson disease.

Du Guangwei G Lewis Mechelle M MM Sica Christopher C Kong Lan L Huang Xuemei X

Annals of neurology 20181219 1

<h4>Objective</h4>Newer magnetic resonance imaging (MRI) techniques have shown promise in capturing early Parkinson disease (PD)-related changes in the substantia nigra pars compacta (SNc), the key pathological loci. Their translational value, however, is hindered by technical complexity and inconsistent results.<h4>Methods</h4>A novel yet simple MRI contrast, the T1w/T2w ratio, was used to study 76 PD patients and 70 controls. The T1w/T2w ratio maps were analyzed using both voxel-based and regi ...[more]

PMID: 30408230

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