Ontology highlight
ABSTRACT:
SUBMITTER: Du G
PROVIDER: S-EPMC6342624 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Du Guangwei G Lewis Mechelle M MM Sica Christopher C Kong Lan L Huang Xuemei X
Annals of neurology 20181219 1
<h4>Objective</h4>Newer magnetic resonance imaging (MRI) techniques have shown promise in capturing early Parkinson disease (PD)-related changes in the substantia nigra pars compacta (SNc), the key pathological loci. Their translational value, however, is hindered by technical complexity and inconsistent results.<h4>Methods</h4>A novel yet simple MRI contrast, the T1w/T2w ratio, was used to study 76 PD patients and 70 controls. The T1w/T2w ratio maps were analyzed using both voxel-based and regi ...[more]