Ontology highlight
ABSTRACT:
SUBMITTER: Bagley SJ
PROVIDER: S-EPMC6342649 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Bagley Stephen J SJ Hwang Wei-Ting WT Brem Steven S Linette Gerald P GP O'Rourke Donald M DM Desai Arati S AS
Journal of neuro-oncology 20181023 1
<h4>Introduction</h4>We sought to determine which therapeutically targetable immune checkpoints, costimulatory signals, and other tumor microenvironment (TME) factors are independently associated with immune cytolytic activity (CYT), a gene expression signature of activated effector T cells, in human glioblastoma (GBM).<h4>Methods</h4>GlioVis was accessed for RNA-seq data from The Cancer Genome Atlas (TCGA). For subjects with treatment-naïve, primary GBM, we quantified mRNA expression of 28 ther ...[more]