Ontology highlight
ABSTRACT:
SUBMITTER: Ricks TJ
PROVIDER: S-EPMC6342655 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Chembiochem : a European journal of chemical biology 20181017 2
Phosphatidylinositol (PI) lipids control critical biological processes, so aberrant biosynthesis often leads to disease. As a result, the capability to track the production and localization of these compounds in cells is vital for elucidating their complex roles. Herein, we report the design, synthesis, and application of clickable myo-inositol probe 1 a for bioorthogonal labeling of PI products. To validate this platform, we initially conducted PI synthase assays to show that 1 a inhibits PI pr ...[more]