Ontology highlight
ABSTRACT:
SUBMITTER: Yang H
PROVIDER: S-EPMC6343133 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Yang Haixia H Wang Weicang W Romano Kymberleigh A KA Gu Min M Sanidad Katherine Z KZ Kim Daeyoung D Yang Jun J Schmidt Birgitta B Panigrahy Dipak D Pei Ruisong R Martin Derek A DA Ozay E Ilker EI Wang Yuxin Y Song Mingyue M Bolling Bradley W BW Xiao Hang H Minter Lisa M LM Yang Guang-Yu GY Liu Zhenhua Z Rey Federico E FE Zhang Guodong G
Science translational medicine 20180501 443
Triclosan (TCS) is a high-volume chemical used as an antimicrobial ingredient in more than 2000 consumer products, such as toothpaste, cosmetics, kitchenware, and toys. We report that brief exposure to TCS, at relatively low doses, causes low-grade colonic inflammation, increases colitis, and exacerbates colitis-associated colon cancer in mice. Exposure to TCS alters gut microbiota in mice, and its proinflammatory effect is attenuated in germ-free mice. In addition, TCS treatment increases activ ...[more]