Ontology highlight
ABSTRACT:
SUBMITTER: Bancone G
PROVIDER: S-EPMC6343352 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Bancone Germana G Menard Didier D Khim Nimol N Kim Saorin S Canier Lydie L Nguong Chea C Phommasone Koukeo K Mayxay Mayfong M Dittrich Sabine S Vongsouvath Malavanh M Fievet Nadine N Le Hesran Jean-Yves JY Briand Valerie V Keomany Sommay S Newton Paul N PN Gorsawun Gornpan G Tardy Kaelan K Chu Cindy S CS Rattanapalroj Orpreeya O Dong Le Thanh LT Quang Huynh Hong HH Tam-Uyen Nguyen N Thuy-Nhien Nguyen N Hien Tran Tinh TT Kalnoky Michael M Nosten Francois F
Malaria journal 20190123 1
<h4>Background</h4>Plasmodium vivax malaria elimination can only be achieved by the deployment of 8-aminoquinolines (primaquine and tafenoquine) in combination with ACT to kill both blood and liver-stage parasites. However, primaquine and the other 8-aminoquinolines cause dose-dependent haemolysis in subjects with G6PD deficiency, an X-linked disorder of red blood cells that is very common in populations living in tropical and subtropical areas. In order to inform safer use of 8-aminoquinolines ...[more]