Role of t-PA and PAI-1 variants in temporal lobe epilepsy in Chinese Han population.

ABSTRACT: BACKGROUND:Epilepsy is one of the most common chronic disabling neurologic diseases. The purpose of our study was to investigate whether there is an association between t-PA (tissue plasminogen activator, rs2020918 and rs4646972), PAI-1 (plasminogen activator inhibitor 1, rs1799768) polymorphisms and susceptibility to temporal lobe epilepsy (TLE) in Chinese Han population. METHOD:One hundred and twenty-one cases of patients who were diagnosed as TLE and 146 normal controls were enrolled and the genotypes of t-PA and PAI-1 were detected by polymerase chain reaction-ligase detection reaction (PCR-LDR) method after the genomic DNA being extracted from peripheral blood. RESULT:There were significant differences for the genotypic frequencies at the two polymorphic sites in t-PA gene between TLE patients and controls (P?=?0.019; P?=?0.001). Furthermore, the frequency of rs2020918 (C > T) with T (CT?+?TT) and rs4646972 (311?bp insertion/-) with 311?bp deletion (311?bp/-?+?-/-) was significantly higher among TLE patients relative to controls respectively (P?=?0.006; P?=?0.001). However, no significant difference in genotypic and allelic frequency was found at the polymorphic site in PAI-1 gene between TLE patients and controls (P?=?0.735). CONCLUSION:We reported for the first time to our knowledge the significant role of the two SNPs in t-PA gene (rs2020918 and rs4646972) in developing susceptibility to TLE in Chinese Han population.

SUBMITTER: Han W 

PROVIDER: S-EPMC6343363 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature