Ontology highlight
ABSTRACT:
SUBMITTER: Engblom C
PROVIDER: S-EPMC6343476 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20171201 6367
Bone marrow-derived myeloid cells can accumulate within tumors and foster cancer outgrowth. Local immune-neoplastic interactions have been intensively investigated, but the contribution of the systemic host environment to tumor growth remains poorly understood. Here, we show in mice and cancer patients (<i>n</i> = 70) that lung adenocarcinomas increase bone stromal activity in the absence of bone metastasis. Animal studies reveal that the cancer-induced bone phenotype involves bone-resident oste ...[more]