Antibody Responses to Antigenic Targets of Recent Exposure Are Associated With Low-Density Parasitemia in Controlled Human Plasmodium falciparum Infections.
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ABSTRACT:
SUBMITTER: van den Hoogen LL
PROVIDER: S-EPMC6343524 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
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Antibody Responses to Antigenic Targets of Recent Exposure Are Associated With Low-Density Parasitemia in Controlled Human <i>Plasmodium falciparum</i> Infections.
van den Hoogen Lotus L LL Walk Jona J Oulton Tate T Reuling Isaie J IJ Reiling Linda L Beeson James G JG Coppel Ross L RL Singh Susheel K SK Singh Susheel K SK Draper Simon J SJ Bousema Teun T Drakeley Chris C Sauerwein Robert R Tetteh Kevin K A KKA
Frontiers in microbiology 20190116
The majority of malaria infections in low transmission settings remain undetectable by conventional diagnostics. A powerful model to identify antibody responses that allow accurate detection of recent exposure to low-density infections is controlled human malaria infection (CHMI) studies in which healthy volunteers are infected with the <i>Plasmodium</i> parasite. We aimed to evaluate antibody responses in malaria-naïve volunteers exposed to a single CHMI using a custom-made protein microarray. ...[more]
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