Ontology highlight
ABSTRACT:
SUBMITTER: Yuan TL
PROVIDER: S-EPMC6343826 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Cell reports 20180201 7
KRAS can bind numerous effector proteins, which activate different downstream signaling events. The best known are RAF, phosphatidylinositide (PI)-3' kinase, and RalGDS families, but many additional direct and indirect effectors have been reported. We have assessed how these effectors contribute to several major phenotypes in a quantitative way, using an arrayed combinatorial siRNA screen in which we knocked down 41 KRAS effectors nodes in 92 cell lines. We show that every cell line has a unique ...[more]