Ontology highlight
ABSTRACT:
SUBMITTER: Zappia MP
PROVIDER: S-EPMC6344057 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Zappia Maria Paula MP Rogers Alice A Islam Abul B M M K ABMMK Frolov Maxim V MV
Cell reports 20190101 3
The importance of the retinoblastoma tumor suppressor protein pRB in cell cycle control is well established. However, less is known about its role in differentiation during animal development. Here, we investigated the role of Rbf, the Drosophila pRB homolog, in adult skeletal muscles. We found that the depletion of Rbf severely reduced muscle growth and altered myofibrillogenesis but only minimally affected myoblast proliferation. We identified an Rbf-dependent transcriptional program in late m ...[more]