Ontology highlight
ABSTRACT:
SUBMITTER: Lownik JC
PROVIDER: S-EPMC6344316 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Lownik Joseph C JC Wimberly Jessica L JL Conrad Daniel H DH Martin Rebecca K RK
Journal of immunology (Baltimore, Md. : 1950) 20190104 3
The role of ICOS and its ligand (ICOSL) have both been shown to be essential for proper humoral responses as well as autoimmune Ab development in mouse models of lupus. In this paper, we report a specific role for the metalloprotease ADAM10 on B cells in regulating both ICOSL and ICOS in a mouse model of increased humoral immunity using B6<sup>mir146a-/-</sup> mice and a model of lymphoproliferative disease using the well-characterized lpr model. B6<sup>lpr</sup> mice lacking ADAM10 on B cells ( ...[more]