Ontology highlight
ABSTRACT:
SUBMITTER: Messmer T
PROVIDER: S-EPMC6344340 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Messmer Tobias T von Meyenn Ferdinand F Savino Aurora A Santos Fátima F Mohammed Hisham H Lun Aaron Tin Long ATL Marioni John C JC Reik Wolf W
Cell reports 20190101 4
Conventional human embryonic stem cells are considered to be primed pluripotent but can be induced to enter a naive state. However, the transcriptional features associated with naive and primed pluripotency are still not fully understood. Here we used single-cell RNA sequencing to characterize the differences between these conditions. We observed that both naive and primed populations were mostly homogeneous with no clear lineage-related structure and identified an intermediate subpopulation of ...[more]