Age- and height-adjusted total kidney volume growth rate in autosomal dominant polycystic kidney diseases.

ABSTRACT:

Background

The Mayo Clinic Image Classification (MIC) was proposed as a renal prognosis prediction model for autosomal dominant polycystic kidney disease (ADPKD). MIC is based on the assumption of exponential constant increase in height-adjusted total kidney volume (HtTKV). HtTKV growth rate is calculated by one-time measurement of HtTKV and age. We named it as an age-adjusted HtTKV growth rate (AHTKV-?). AHTKV-? was compared with HtTKV slope measured by at least two HtTKV values.

Methods

Comparison of repeatability between AHTKV-? and HtTKV slope, correlation of subgroups divided according to baseline AHTKV-? and HtTKV slope with disease manifestations, estimated glomerular filtration rate (eGFR) slope, and renal survival were analyzed in 296 patients with ADPKD. PKD genotype influences were compared between AHTKV-? and HtTKV slope in 88 patients with characterized PKD mutations.

Results

Absolute differences between baseline and follow-up measures were significantly larger for the HtTKV slope than for AHTKV-? (P?ConclusionMIC is a good renal prediction model applicable to Japanese patients also. AHTKV-? can be a more sensitive and reliable indicator in TKV growth rate than HtTKV slope.

SUBMITTER: Higashihara E 

PROVIDER: S-EPMC6344392 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature