Comparative oncogenomics identifies combinations of driver genes and drug targets in BRCA1-mutated breast cancer.
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ABSTRACT:
SUBMITTER: Annunziato S
PROVIDER: S-EPMC6344487 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Publications
Comparative oncogenomics identifies combinations of driver genes and drug targets in BRCA1-mutated breast cancer.
Annunziato Stefano S de Ruiter Julian R JR Henneman Linda L Brambillasca Chiara S CS Lutz Catrin C Vaillant François F Ferrante Federica F Drenth Anne Paulien AP van der Burg Eline E Siteur Bjørn B van Gerwen Bas B de Bruijn Roebi R van Miltenburg Martine H MH Huijbers Ivo J IJ van de Ven Marieke M Visvader Jane E JE Lindeman Geoffrey J GJ Wessels Lodewyk F A LFA Jonkers Jos J
Nature communications 20190123 1
BRCA1-mutated breast cancer is primarily driven by DNA copy-number alterations (CNAs) containing large numbers of candidate driver genes. Validation of these candidates requires novel approaches for high-throughput in vivo perturbation of gene function. Here we develop genetically engineered mouse models (GEMMs) of BRCA1-deficient breast cancer that permit rapid introduction of putative drivers by either retargeting of GEMM-derived embryonic stem cells, lentivirus-mediated somatic overexpression ...[more]
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