Ontology highlight
ABSTRACT:
SUBMITTER: Jin Y
PROVIDER: S-EPMC6344500 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Jin Ying Y Roberts Genevieve H L GHL Ferrara Tracey M TM Ben Songtao S van Geel Nanja N Wolkerstorfer Albert A Ezzedine Khaled K Siebert Janet J Neff Charles P CP Palmer Brent E BE Santorico Stephanie A SA Spritz Richard A RA
Nature communications 20190123 1
Vitiligo is an autoimmune disease in which melanocyte destruction causes skin depigmentation, with 49 loci known from previous GWAS. Aiming to define vitiligo subtypes, we discovered that age-of-onset is bimodal; one-third of cases have early onset (mean 10.3 years) and two-thirds later onset (mean 34.0 years). In the early-onset subgroup we found novel association with MHC class II region indel rs145954018, and independent association with the principal MHC class II locus from previous GWAS, re ...[more]