Ontology highlight
ABSTRACT:
SUBMITTER: Horton A
PROVIDER: S-EPMC6344890 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Journal of medicinal chemistry 20180507 10
Nitric oxide (NO) mimetics and other agents capable of enhancing NO/cGMP signaling have demonstrated efficacy as potential therapies for Alzheimer's disease. A group of thiol-dependent NO mimetics known as furoxans may be designed to exhibit attenuated reactivity to provide slow onset NO effects. The present study describes the design, synthesis, and evaluation of a furoxan library resulting in the identification of a prototype furoxan, 5a, which was profiled for use in the central nervous syste ...[more]