Ontology highlight
ABSTRACT:
SUBMITTER: Pabis M
PROVIDER: S-EPMC6344896 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Pabis Marta M Popowicz Grzegorz M GM Stehle Ralf R Fernández-Ramos David D Asami Sam S Warner Lisa L García-Mauriño Sofía M SM Schlundt Andreas A Martínez-Chantar María L ML Díaz-Moreno Irene I Sattler Michael M
Nucleic acids research 20190101 2
HuR/ELAVL1 is an RNA-binding protein involved in differentiation and stress response that acts primarily by stabilizing messenger RNA (mRNA) targets. HuR comprises three RNA recognition motifs (RRMs) where the structure and RNA binding of RRM3 and of full-length HuR remain poorly understood. Here, we report crystal structures of RRM3 free and bound to cognate RNAs. Our structural, NMR and biochemical data show that RRM3 mediates canonical RNA interactions and reveal molecular details of a dimeri ...[more]