The Microbial Metabolite Butyrate Stimulates Bone Formation via T Regulatory Cell-Mediated Regulation of WNT10B Expression.
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ABSTRACT:
SUBMITTER: Tyagi AM
PROVIDER: S-EPMC6345170 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Publications
The Microbial Metabolite Butyrate Stimulates Bone Formation via T Regulatory Cell-Mediated Regulation of WNT10B Expression.
Tyagi Abdul Malik AM Yu Mingcan M Darby Trevor M TM Vaccaro Chiara C Li Jau-Yi JY Owens Joshua A JA Hsu Emory E Adams Jonathan J Weitzmann M Neale MN Jones Rheinallt M RM Pacifici Roberto R
Immunity 20181113 6
Nutritional supplementation with probiotics can prevent pathologic bone loss. Here we examined the impact of supplementation with Lactobacillus rhamnosus GG (LGG) on bone homeostasis in eugonadic young mice. Micro-computed tomography revealed that LGG increased trabecular bone volume in mice, which was due to increased bone formation. Butyrate produced in the gut following LGG ingestion, or butyrate fed directly to germ-free mice, induced the expansion of intestinal and bone marrow (BM) regulato ...[more]
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