Dataset Information

Corticoamygdala Transfer of Socially Derived Information Gates Observational Learning.

ABSTRACT: Observational learning is a powerful survival tool allowing individuals to learn about threat-predictive stimuli without directly experiencing the pairing of the predictive cue and punishment. This ability has been linked to the anterior cingulate cortex (ACC) and the basolateral amygdala (BLA). To investigate how information is encoded and transmitted through this circuit, we performed electrophysiological recordings in mice observing a demonstrator mouse undergo associative fear conditioning and found that BLA-projecting ACC (ACC?BLA) neurons preferentially encode socially derived aversive cue information. Inhibition of ACC?BLA alters real-time amygdala representation of the aversive cue during observational conditioning. Selective inhibition of the ACC?BLA projection impaired acquisition, but not expression, of observational fear conditioning. We show that information derived from observation about the aversive value of the cue is transmitted from the ACC to the BLA and that this routing of information is critically instructive for observational fear conditioning. VIDEO ABSTRACT.

SUBMITTER: Allsop SA

PROVIDER: S-EPMC6345560 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature

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Corticoamygdala Transfer of Socially Derived Information Gates Observational Learning.

Allsop Stephen A SA Wichmann Romy R Mills Fergil F Burgos-Robles Anthony A Chang Chia-Jung CJ Felix-Ortiz Ada C AC Vienne Alienor A Beyeler Anna A Izadmehr Ehsan M EM Glober Gordon G Cum Meghan I MI Stergiadou Johanna J Anandalingam Kavitha K KK Farris Kathryn K Namburi Praneeth P Leppla Christopher A CA Weddington Javier C JC Nieh Edward H EH Smith Anne C AC Ba Demba D Brown Emery N EN Tye Kay M KM

Cell 20180503 6

Observational learning is a powerful survival tool allowing individuals to learn about threat-predictive stimuli without directly experiencing the pairing of the predictive cue and punishment. This ability has been linked to the anterior cingulate cortex (ACC) and the basolateral amygdala (BLA). To investigate how information is encoded and transmitted through this circuit, we performed electrophysiological recordings in mice observing a demonstrator mouse undergo associative fear conditioning a ...[more]

PMID: 29731170

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Project description:Social feedback can selectively enhance learning in diverse domains. Relevant neurocognitive mechanisms have been studied mainly in healthy persons, yielding correlational findings. Neurodegenerative lesion models, coupled with multimodal brain measures, can complement standard approaches by revealing direct multidimensional correlates of the phenomenon. To this end, we assessed socially reinforced and non-socially reinforced learning in 40 healthy participants as well as persons with behavioural variant frontotemporal dementia (n = 21), Parkinson's disease (n = 31) and Alzheimer's disease (n = 20). These conditions are typified by predominant deficits in social cognition, feedback-based learning and associative learning, respectively, although all three domains may be partly compromised in the other conditions. We combined a validated behavioural task with ongoing EEG signatures of implicit learning (medial frontal negativity) and offline MRI measures (voxel-based morphometry). In healthy participants, learning was facilitated by social feedback relative to non-social feedback. In comparison with controls, this effect was specifically impaired in behavioural variant frontotemporal dementia and Parkinson's disease, while unspecific learning deficits (across social and non-social conditions) were observed in Alzheimer's disease. EEG results showed increased medial frontal negativity in healthy controls during social feedback and learning. Such a modulation was selectively disrupted in behavioural variant frontotemporal dementia. Neuroanatomical results revealed extended temporo-parietal and fronto-limbic correlates of socially reinforced learning, with specific temporo-parietal associations in behavioural variant frontotemporal dementia and predominantly fronto-limbic regions in Alzheimer's disease. In contrast, non-socially reinforced learning was consistently linked to medial temporal/hippocampal regions. No associations with cortical volume were found in Parkinson's disease. Results are consistent with core social deficits in behavioural variant frontotemporal dementia, subtle disruptions in ongoing feedback-mechanisms and social processes in Parkinson's disease and generalized learning alterations in Alzheimer's disease. This multimodal approach highlights the impact of different neurodegenerative profiles on learning and social feedback. Our findings inform a promising theoretical and clinical agenda in the fields of social learning, socially reinforced learning and neurodegeneration.

Dataset Information

Corticoamygdala Transfer of Socially Derived Information Gates Observational Learning.

Publications

Corticoamygdala Transfer of Socially Derived Information Gates Observational Learning.

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