Ontology highlight
ABSTRACT:
SUBMITTER: Almeida-Santos AF
PROVIDER: S-EPMC6345767 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Almeida-Santos Ana F AF Carvalho Vinícius R VR Jaimes Laura F LF de Castro Caio M CM Pinto Hyorrana P HP Oliveira Tadeu P D TPD Vieira Luciene B LB Moraes Márcio F D MFD Pereira Grace S GS
Scientific reports 20190124 1
The absence of companion may jeopardize mental health in social animals. Here, we tested the hypothesis that social isolation impairs social recognition memory by altering the excitability and the dialog between the olfactory bulb (OB) and the dorsal hippocampus (dHIP). Adult male Swiss mice were kept grouped (GH) or isolated (SI) for 7 days. Social memory (LTM) was evaluated using social recognition test. SI increased glutamate release in the OB, while decreased in the dHIP. Blocking AMPA and N ...[more]