Neuropathological correlates and genetic architecture of microglial activation in elderly human brain.
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ABSTRACT:
SUBMITTER: Felsky D
PROVIDER: S-EPMC6345810 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Publications
Neuropathological correlates and genetic architecture of microglial activation in elderly human brain.
Felsky Daniel D Roostaei Tina T Nho Kwangsik K Risacher Shannon L SL Bradshaw Elizabeth M EM Petyuk Vlad V Schneider Julie A JA Saykin Andrew A Bennett David A DA De Jager Philip L PL
Nature communications 20190124 1
Microglia, the resident immune cells of the brain, have important roles in brain health. However, little is known about the regulation and consequences of microglial activation in the aging human brain. Here we report that the proportion of morphologically activated microglia (PAM) in postmortem cortical tissue is strongly associated with β-amyloid, tau-related neuropathology, and the rate of cognitive decline. Effect sizes for PAM measures are substantial, comparable to that of APOE ε4, the str ...[more]
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