Ontology highlight
ABSTRACT:
SUBMITTER: Costa DVS
PROVIDER: S-EPMC6345953 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Costa Deiziane V S DVS Bon-Frauches Ana C AC Silva Angeline M H P AMHP Lima-Júnior Roberto C P RCP Martins Conceição S CS Leitão Renata F C RFC Freitas Gutierrez B GB Castelucci Patricia P Bolick David T DT Guerrant Richard L RL Warren Cirle A CA Moura-Neto Vivaldo V Brito Gerly A C GAC
Scientific reports 20190124 1
5-Fluorouracil (5-FU) is an anticancer agent whose main side effects include intestinal mucositis associated with intestinal motility alterations maybe due to an effect on the enteric nervous system (ENS), but the underlying mechanism remains unclear. In this report, we used an animal model to investigate the participation of the S100B/RAGE/NFκB pathway in intestinal mucositis and enteric neurotoxicity caused by 5-FU (450 mg/kg, IP, single dose). 5-FU induced intestinal damage observed by shorte ...[more]