Dataset Information

First Detection and Genome Sequence of Senecavirus A in Vietnam.

ABSTRACT: In 2018, senecavirus A was detected for the first time in Vietnam. This report contains the first complete genome of a senecavirus A isolate collected from pigs in Kon Tum Province, Vietnam. This novel incursion has substantial implications for regional control of vesicular transboundary diseases.

SUBMITTER: Arzt J

PROVIDER: S-EPMC6346150 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature

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First Detection and Genome Sequence of Senecavirus A in Vietnam.

Arzt Jonathan J Bertram Miranda R MR Vu Le T LT Pauszek Steven J SJ Hartwig Ethan J EJ Smoliga George R GR Palinski Rachel R Stenfeldt Carolina C Fish Ian H IH Hoang Bui H BH Phuong Nguyen T NT Hung Vo V VV Vu Pham P PP Dung Nguyen K NK Dong Pham V PV Tien Nguyen N NN Dung Do H DH

Microbiology resource announcements 20190117 3

In 2018, senecavirus A was detected for the first time in Vietnam. This report contains the first complete genome of a senecavirus A isolate collected from pigs in Kon Tum Province, Vietnam. This novel incursion has substantial implications for regional control of vesicular transboundary diseases. ...[more]

PMID: 30687818

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Project description:IntroductionDengue hemorrhagic fever is caused by four serotypes of dengue viruses transmitted by mosquitoes. In Vietnam, dengue outbreaks occur every year, and all four serotypes have been found circulating with the dominant one varying over time. However, in 2017 an unusual dengue fever outbreak occurred in the North of Vietnam, predominantly caused by DENV1 (92%) and DENV2 (7.3%). The objective of the present study was to obtain and characterize the full-length genome sequence of seven DENV2 strains in 2017 epidemic.Materials and methodsWhole-genome sequencing of seven DENV2 isolates from the 2017 outbreak were obtained using the Illumina MiSeq next generation sequencer system. Complete genome sequences were then analyzed to find out genetic variants and genetic relationships between these DENV2 with other strains that circulated in Vietnam previously and other regions of the world.ResultsThe complete genome sequence of seven DENV2 isolates in the 2017 dengue outbreak comprised 10,696 nucleotides with an open reading frame coding for 3392 amino acids. The genome analysis showed only a small number of amino acid changes which were obtained in all genes, in which a few amino acids substitutions were distributed over the positions such as G156 (NS1), V106 (NS2A), and L258/T260 (NS5). The phylogenetic analysis revealed that the DENV2 isolates in the 2017 outbreak were most closely related to the dengue virus from India in 2006, suggesting that the causative virus originated from the DENV2 that caused dengue hemorrhagic fever in 2006 in India.ConclusionThe first complete genome sequences of seven DENV2 isolates in the 2017 dengue outbreak in Northern Vietnam were successfully obtained. The genetic and phylogenetic data indicated that these DENV2 isolates were not causative virus circulating in Vietnam previously but originated from India in 2006. These data are emerging and providing valuable information for the management and surveillance of dengue in Vietnam.

Dataset Information

First Detection and Genome Sequence of Senecavirus A in Vietnam.

Publications

First Detection and Genome Sequence of Senecavirus A in Vietnam.

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