Synthesis of amorpha-4,11-diene from dihydroartemisinic acid.
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ABSTRACT:
SUBMITTER: Schwertz G
PROVIDER: S-EPMC6346372 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
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Synthesis of amorpha-4,11-diene from dihydroartemisinic acid.
Schwertz Geoffrey G Zanetti Andrea A Nascimento de Oliveira Marllon M Gomez Fernandez Mario Andrès MA Dioury Fabienne F Cossy Janine J Amara Zacharias Z
Tetrahedron 20190201 6
Amorphadiene is a natural product involved in the biosynthesis of the antimalarial drug artemisinin. A convenient four-step synthesis of amorphadiene, starting from commercially available dihydroartemisinic acid, is reported. The targeted molecule is isolated with an overall yield of 85% on a multi-gram scale in four steps with only one chromatography. ...[more]
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