Ontology highlight
ABSTRACT:
SUBMITTER: Woods JJ
PROVIDER: S-EPMC6346394 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
ACS central science 20190104 1
Mitochondrial Ca<sup>2+</sup> (<sub>m</sub>Ca<sup>2+</sup>) uptake mediated by the mitochondrial calcium uniporter (MCU) plays a critical role in signal transduction, bioenergetics, and cell death, and its dysregulation is linked to several human diseases. In this study, we report a new ruthenium complex Ru265 that is cell-permeable, minimally toxic, and highly potent with respect to MCU inhibition. Cells treated with Ru265 show inhibited MCU activity without any effect on cytosolic Ca<sup>2+</s ...[more]