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Salinomycin decreases feline sarcoma and carcinoma cell viability when combined with doxorubicin.

ABSTRACT: BACKGROUND:Cancer is a significant health threat in cats. Chemoresistance is prevalent in solid tumors. The ionophore salinomycin has anti-cancer properties and may work synergistically with chemotherapeutics. The purpose of our study was to determine if salinomycin could decrease cancer cell viability when combined with doxorubicin in feline sarcoma and carcinoma cells. RESULTS:We established two new feline injection-site sarcoma cell lines, B4 and C10, and confirmed their tumorigenic potential in athymic nude mice. B4 was more resistant to doxorubicin than C10. Dose-dependent effects were not observed until 92??M in B4 cells (p =?0.0006) vs. 9.2??M (p =?0.0004) in C10 cells. Dose-dependent effects of salinomycin were observed at 15??M in B4 cells (p =?0.025) and at 10??M in C10 cells (p =?0.020). Doxorubicin plus 5??M salinomycin decreased viability of B4 cells compared to either agent alone, but only at supra-pharmacological doxorubicin concentrations. However, doxorubicin plus 5??M salinomycin decreased viability of C10 cells compared to either agent alone at doxorubicin concentrations that can be achieved in vivo (1.84 and 4.6??M, p

SUBMITTER: Borlle L

PROVIDER: S-EPMC6346515 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature

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Salinomycin decreases feline sarcoma and carcinoma cell viability when combined with doxorubicin.

Borlle Lucia L Dergham Abdo A Wund Zacharie Z Zumbo Brittany B Southard Teresa T Hume Kelly R KR

BMC veterinary research 20190124 1

<h4>Background</h4>Cancer is a significant health threat in cats. Chemoresistance is prevalent in solid tumors. The ionophore salinomycin has anti-cancer properties and may work synergistically with chemotherapeutics. The purpose of our study was to determine if salinomycin could decrease cancer cell viability when combined with doxorubicin in feline sarcoma and carcinoma cells.<h4>Results</h4>We established two new feline injection-site sarcoma cell lines, B4 and C10, and confirmed their tumori ...[more]

PMID: 30678671

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Salinomycin decreases feline sarcoma and carcinoma cell viability when combined with doxorubicin.

Publications

Salinomycin decreases feline sarcoma and carcinoma cell viability when combined with doxorubicin.

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