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Current perspectives on mechanisms of ribonucleotide incorporation and processing in mammalian DNA.

ABSTRACT: Ribonucleotides, which are RNA precursors, are often incorporated into DNA during replication. Although embedded ribonucleotides in the genome are efficiently removed by canonical ribonucleotide excision repair (RER), inactivation of RER causes genomic ribonucleotide accumulation, leading to various abnormalities in cells. Mutation of genes encoding factors involved in RER is associated with the neuroinflammatory autoimmune disorder Aicardi-Goutières syndrome. Over the last decade, the biological impact of ribonucleotides in the genome has attracted much attention. In the present review, we particularly focus on recent studies that have elucidated possible mechanisms of ribonucleotide incorporation and repair and their significance in mammals.

SUBMITTER: Sassa A

PROVIDER: S-EPMC6346524 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Current perspectives on mechanisms of ribonucleotide incorporation and processing in mammalian DNA.

Sassa Akira A Yasui Manabu M Honma Masamitsu M

Genes and environment : the official journal of the Japanese Environmental Mutagen Society 20190125

Ribonucleotides, which are RNA precursors, are often incorporated into DNA during replication. Although embedded ribonucleotides in the genome are efficiently removed by canonical ribonucleotide excision repair (RER), inactivation of RER causes genomic ribonucleotide accumulation, leading to various abnormalities in cells. Mutation of genes encoding factors involved in RER is associated with the neuroinflammatory autoimmune disorder Aicardi-Goutières syndrome. Over the last decade, the biologica ...[more]

PMID: 30700998

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