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Genetic variation in the leukotriene pathway is associated with myocardial infarction in the Chinese population.


ABSTRACT: BACKGROUND:Genetic variation in the genes ALOX5 (arachidonate 5-lipoxygenase), ALOX5AP (arachidonate 5-lipoxygenase-activating protein) and LTA4H (leukotriene A4 hydrolase) has previously been shown to contribute to the risk of MI (myocardial infarction) in Caucasian and African American populations. All genes encode proteins playing a role in the synthesis of the pro-inflammatory leukotriene B mediators, possibly providing a link between MI and inflammation. The aim of the present study was to investigate whether these associations could be confirmed in the study of China MI patients. The study included 401 Han Chinese MI patients and 409 controls. Six tag single nucleotide polymorphisms (SNPs)-ALOX5 rs12762303 and rs12264801, ALOX5AP rs10507391, LTA4H rs2072512, rs2540487 and rs2540477-were selected. SNP genotyping was performed by an improved multiplex ligation detection reaction assay. RESULTS:The rs2540487 genotype was associated with the risk of MI in overdominant model (P?=?0.008). rs12762303 and rs10507391 SNPs were significantly associated with lipid levels in MI patients (P??0.05 for all). CONCLUSIONS:Taken together, this study provides additional evidence that functional genetic variation of the LT pathway can mediate atherogenic processes and the risk of MI in Chinese.

SUBMITTER: Li Y 

PROVIDER: S-EPMC6346589 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature

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Genetic variation in the leukotriene pathway is associated with myocardial infarction in the Chinese population.

Li Yilan Y   Xu Xueming X   Zhang Dandan D   Cheng Wei W   Zhang Yanan Y   Yu Bo B   Zhang Yao Y  

Lipids in health and disease 20190124 1


<h4>Background</h4>Genetic variation in the genes ALOX5 (arachidonate 5-lipoxygenase), ALOX5AP (arachidonate 5-lipoxygenase-activating protein) and LTA4H (leukotriene A4 hydrolase) has previously been shown to contribute to the risk of MI (myocardial infarction) in Caucasian and African American populations. All genes encode proteins playing a role in the synthesis of the pro-inflammatory leukotriene B mediators, possibly providing a link between MI and inflammation. The aim of the present study  ...[more]

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