Dataset Information

Quantile Regression in the Secondary Analysis of Case-Control Data.

ABSTRACT: Case-control design is widely used in epidemiology and other fields to identify factors associated with a disease. Data collected from existing case-control studies can also provide a cost-effective way to investigate the association of risk factors with secondary outcomes. When the secondary outcome is a continuous random variable, most of the existing methods focus on the statistical inference on the mean of the secondary outcome. In this paper, we propose a quantile-based approach to facilitating a comprehensive investigation of covariates' effects on multiple quantiles of the secondary outcome. We construct a new family of estimating equations combining observed and pseudo outcomes, which lead to consistent estimation of conditional quantiles using case-control data. Simulations are conducted to evaluate the performance of our proposed approach, and a case-control study on genetic association with asthma is used to demonstrate the method.

SUBMITTER: Wei Y

PROVIDER: S-EPMC6347118 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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Publications

Quantile Regression in the Secondary Analysis of Case-Control Data.

Wei Ying Y Song Xiaoyu X Liu Mengling M Ionita-Laza Iuliana I Reibman Joan J

Journal of the American Statistical Association 20160505 513

Case-control design is widely used in epidemiology and other fields to identify factors associated with a disease. Data collected from existing case-control studies can also provide a cost-effective way to investigate the association of risk factors with secondary outcomes. When the secondary outcome is a continuous random variable, most of the existing methods focus on the statistical inference on the mean of the secondary outcome. In this paper, we propose a quantile-based approach to facilita ...[more]

PMID: 30686848

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Dataset Information

Quantile Regression in the Secondary Analysis of Case-Control Data.

Publications

Quantile Regression in the Secondary Analysis of Case-Control Data.

Similar Datasets

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