Ontology highlight
ABSTRACT:
SUBMITTER: Suboticki T
PROVIDER: S-EPMC6347554 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Subotički Tijana T Mitrović Ajtić Olivera O Beleslin-Čokić Bojana B BB Bjelica Sunčica S Djikić Dragoslava D Diklić Miloš M Leković Danijela D Gotić Mirjana M Santibanez Juan F JF Noguchi Constance T CT Čokić Vladan P VP
Cell biology international 20190107 2
Myeloproliferative neoplasms (MPNs) are developing resistance to therapy by JAK1/2 inhibitor ruxolitinib. To explore the mechanism of ruxolitinib's limited effect, we examined the JAK1/2 mediated induction of proliferation related ERK1/2 and AKT signaling by proinflammatory interleukin-6 (IL-6) in MPN granulocytes and JAK2V617F mutated human erythroleukemia (HEL) cells. We found that JAK1/2 or JAK2 inhibition prevented the IL-6 activation of STAT3 and AKT pathways in polycythemia vera and HEL ce ...[more]