Ontology highlight
ABSTRACT:
SUBMITTER: Isgrig K
PROVIDER: S-EPMC6347594 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Nature communications 20190125 1
Adeno-associated virus (AAV) has been successfully used to deliver gene therapy to improve auditory function in mouse models of hereditary hearing loss. Many forms of hereditary hearing loss have mutations which affect the cochlear hair cells, the mechanosensory cells which allow for sound detection and processing. While most conventional AAVs infect inner hair cells (IHCs) with various efficiencies, they infect outer hair cells (OHCs) and supporting cells at lower levels in the cochlea. Here we ...[more]