Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Y
PROVIDER: S-EPMC6347623 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Zhang Yuqing Y Zhou Feiye F Bai Mengyao M Liu Yun Y Zhang Linlin L Zhu Qin Q Bi Yufang Y Ning Guang G Zhou Libin L Wang Xiao X
Cell death & disease 20190125 2
Protein acetylation has a crucial role in energy metabolism. Here we performed the first large-scale profiling of acetylome in rat islets, showing that almost all enzymes in core metabolic pathways related to insulin secretion were acetylated. Label-free quantitative acetylome of islets in response to high glucose revealed hyperacetylation of enzymes involved in fatty acid β-oxidation (FAO), including trifunctional enzyme subunit alpha (ECHA). Acetylation decreased the protein stability of ECHA ...[more]