Ontology highlight
ABSTRACT:
SUBMITTER: Zhang S
PROVIDER: S-EPMC6347692 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Zhang Suping S Zhang Han H Ghia Emanuela M EM Huang Jiajia J Wu Liufeng L Zhang Jianchao J Lam Sharon S Lei Yang Y He Jinsong J Cui Bing B Widhopf George F GF Yu Jian J Schwab Richard R Messer Karen K Jiang Wenqi W Parker Barbara A BA Carson Dennis A DA Kipps Thomas J TJ
Proceedings of the National Academy of Sciences of the United States of America 20190108 4
Breast cancers enduring treatment with chemotherapy may be enriched for cancer stem cells or tumor-initiating cells, which have an enhanced capacity for self-renewal, tumor initiation, and/or metastasis. Breast cancer cells that express the type I tyrosine kinaselike orphan receptor ROR1 also may have such features. Here we find that the expression of ROR1 increased in breast cancer cells following treatment with chemotherapy, which also enhanced expression of genes induced by the activation of ...[more]