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RhoA/rho-kinase, nitric oxide and inflammatory response in LIMA during OPCABG with isoflurane preconditioning.


ABSTRACT: BACKGROUND:Grafting vessel with LIMA to the left anterior descending coronary artery plays a most important role in the long-term prognosis of OPCABG surgery. The aim of this study was to compare the effects of isoflurane preconditioning on miRs and mRNAs levels in the left internal mammary arterie (LIMA) graft with propofol in patients undergoing off-pump coronary artery bypass surgery (OPCABG). METHODS:Patients were randomly assigned to receive either propofol (n?=?15), or interrupted isoflurane (n?=?15). In group P, propofol administration was continued at 3-5?mg/kg/h intravenous injection for the duration of surgery. Five minutes prior to incision, patients of the isoflurane group (group Iso) received 2?cycles of 1 MAC isoflurane. RESULTS:miR-221 were significantly lower in group Iso (P?

SUBMITTER: Zhang L 

PROVIDER: S-EPMC6347768 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature

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RhoA/rho-kinase, nitric oxide and inflammatory response in LIMA during OPCABG with isoflurane preconditioning.

Zhang Liang L   Wang Cheng-Bin CB   Li Bo B   Lin Duo-Mao DM   Ma Jun J  

Journal of cardiothoracic surgery 20190125 1


<h4>Background</h4>Grafting vessel with LIMA to the left anterior descending coronary artery plays a most important role in the long-term prognosis of OPCABG surgery. The aim of this study was to compare the effects of isoflurane preconditioning on miRs and mRNAs levels in the left internal mammary arterie (LIMA) graft with propofol in patients undergoing off-pump coronary artery bypass surgery (OPCABG).<h4>Methods</h4>Patients were randomly assigned to receive either propofol (n = 15), or inter  ...[more]

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