Development of Activity-Based Proteomic Probes for Protein Citrullination.
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ABSTRACT:
SUBMITTER: Nemmara VV
PROVIDER: S-EPMC6348022 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Publications
Development of Activity-Based Proteomic Probes for Protein Citrullination.
Nemmara Venkatesh V VV Thompson Paul R PR
Current topics in microbiology and immunology 20190101
Protein arginine deiminases (PADs) catalyze the post-translational deimination of peptidyl arginine to form peptidyl citrulline. This modification is increased in multiple inflammatory diseases and in certain cancers. PADs regulate a variety of signaling pathways including apoptosis, terminal differentiation, and transcriptional regulation. Activity-based protein profiling (ABPP) probes have been developed to understand the role of the PADs in vivo and to investigate the effect of protein citrul ...[more]
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